Malignant astrocytic glioma: genetics, biology, and paths to treatment
نویسندگان
چکیده
منابع مشابه
Malignant astrocytic glioma: genetics, biology, and paths to treatment.
Malignant astrocytic gliomas such as glioblastoma are the most common and lethal intracranial tumors. These cancers exhibit a relentless malignant progression characterized by widespread invasion throughout the brain, resistance to traditional and newer targeted therapeutic approaches, destruction of normal brain tissue, and certain death. The recent confluence of advances in stem cell biology,...
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Gliomas are rare compared to cancers of the breast, lung, or colon, but few malignancies are more devastating. While no therapeutic breakthroughs have occurred, the treatment of glioma is improving. Surgical care is improving. Magnetic resonance imaging and intraoperative mapping studies are leading to safer, more complete resections. With scan-guided stereotactic biopsy, unresectable tumors ca...
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A large number of oncogenes have been identified as aberrant in gliomas, but only the erbB oncogene (gene encoding the epidermal growth factor receptor [EGFR]) is amplified in an appreciable number. The loss or mutation of tumor-suppressor genes located on different autosomes may be associated with progression of malignant gliomas. The p53 tumor-suppressor gene (located on chromosome 17) is fre...
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Gliomas are rare compared to cancers of the breast, lung, or colon, but few malignancies are more devastating. While no therapeutic breakthroughs have occurred, the treatment of glioma is improving. Surgical care is improving. Magnetic resonance imaging and intraoperative mapping studies are leading to safer, more complete resections. With scan-guided stereotactic biopsy, unresectable tumors ca...
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Malignant gliomas (glioblastoma multiforme and anaplastic astrocytoma) occur more frequently than other types of primary central nervous system tumors, having a combined incidence of 5-8/100,000 population. Even with aggressive treatment using surgery, radiation, and chemotherapy, median reported survival is less than 1 year. Temozolomide, a new drug, has shown promise in treating malignant gli...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2007
ISSN: 0890-9369
DOI: 10.1101/gad.1596707